The inimitable American designer launched her namesake fashion line in 2004, and its subsequent wild success—the brand has flourished into a multifaceted, multinational lifestyle powerhouse—is about as inspiring as it gets. Her polished, easy, utterly original style comes through in every piece she makes, from brilliant straight-off-the-runway separates to the instantly-covetable shoes and bags. We count on her for unique, wear-it-forever looks that just plain make us look good, no matter what the occasion.