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Part hotel, part contemporary art gallery, 21c Museum Hotel occupies a massive warehouse from 1900 (formerly the headquarters of a wholesale hardware company). The whole art aspect hits you immediately: There’s over 10,500 square feet of exhibition space, filled with rotating shows and installations. Guest rooms are spare but comfortable, each featuring prints from local photographers. Spring for a terrace suite and you get your own (huge) outdoor space, complete with sofas and dining table for alfresco meals. Three of the suites were designed with artists: one by actor Adrian Grenier, another a collaboration between painter Sebastiaan Bremer and musician-composer Josephine Wiggs, and a third by Yung Jake.

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