The city is somewhat overrun by mezcal bars, as the smoky agave-based drink has sky-rocketed in terms of popularity, but La Botica was one of the originals, and continues to support small, independent distilleries, which is why it makes our list. Their mezcals, which they serve neat with orange slices and traditional bar snacks on the side, are sourced from all parts of the country and like serious sommeliers, the staff are all passionate about provenance and tasting notes. It’s a good first stop for a long night out, and it’s also a great place to get an education on the ever-popular drink.

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