The neo-Gothic Grand Hotel et de Milan has been open since 1863–and run by three generations of the same family. Local design firm Dimore Studio recently renovated the interiors, which marry classic elements (parquet wood floors, Oriental rugs) with modern touches like custom made seating and sleek, sculptural lighting. Given its history, it’s a cultural experience on its own, and it’s within walking distance of some of the city’s best—including La Scala and the fashion district on Via Montenapoleone.

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