Occupying a fifteenth-century, Brunelleschi-designed Renaissance palace, the St. Regis is, like the Four Seasons, a sumptuous historical experience. Rooms are worthy of the architecture, with plenty of velvet and silk accents; many have views of the Arno. Take full advantage of the hotel’s knowledgeable concierge and services, which include tours of the city and countryside in the St. Regis Bentley, as well as tours of Florence’s galleries and museums with the hotel’s own in-house curator.

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