Hands down, Masterpiece Deli makes the best sandwiches in Denver, and on Saturday and Sunday mornings, you’ll find lines out the door for the many hangover-curing items on their menu. The guys here (the same people who are behind Old Major, just up the street) care deeply about sourcing, finding the very best cured meats and cheeses, many of them imported. While the breakfast sandwiches (you can pick from a bunch of different meats) are a universal favorite, we also love the Italian, the Cubano, the smoked turkey and brie, and—so heavy but so absolutely, definitively worth it—the 12-hour braised beef brisket. The original’s in LoHi, but they also have a location in Uptown.

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