MACRENE actives

High Performance Face Cream

US $225.00

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MACRENE actives

High Performance Face Cream

US $225.00

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This bestselling cream from top New York dermatologist Macrene Alexiades is supercharged with over fifty plant-derived active ingredients—it’s just amazing for your skin. With three Harvard degrees, a Fulbright, and countless dermatological honors to her name, Dr. Alexiades first developed the cream for her patients, “so they could see me less!” she laughs. Superhydrators like olive oil, purslane, and hyaluronic acid; research-backed peptides; red and blue algae; fatty acids; and stable forms of powerful antioxidants, like vitamins C and E, work synergistically to reduce the appearance of fine lines, redness, sun damage, dryness, and dullness while fighting free radicals and working to refresh and rejuvenate skin.

  • 30ml/1 oz
  • Apply twice daily, after cleansing with lukewarm water and Macrene actives High Performance Cleanser
  • Pat dry and while skin is still damp, apply a pea size amount to each quadrant of the face and gently smooth over the area until absorbed


Caution: For external use only. Keep out of reach of children. Avoid direct contact with eyes. If irritation develops, discontinue use and consult a physician. Store in cool, dark place. No animal ingredients or testing.


Need help figuring out where to add this into your routine? Have a specific question? Send a message over to [email protected].

Water, Squalane1,2,3, Glycerin1, Hydrogenated Ethylhexyl Olivate1,3, Hydrogenated Olive Oil Unsaponifiables1,3, Cetyl Alcohol1, Tetrahexyldecyl Ascorbate, Helianthus annuus (Sunflower) Seed Oil Unsaponifiables1, Acetyl Glucosamine, Stearic Acid1,3, Sorbitan Stearate, Copper Lysinate, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Resveratrol1, Scenedesmus rubescens (Microalgae) Extract1, Plankton Extract1, Arabidopsis thaliana Extract1, Micrococcus Extract, Leontopodium alpinum (Edelweiss) Flower/Leaf Extract1,3, Ergothioneine, Coffea arabica (Coffee) seed Extract1,2,3, Ilex Paraguariensis (Yerba Mate Tea) Leaf Extract1,2,3, Chrysanthemum parthenium (Feverfew) Extract1,2,3, Theobroma cacao (Cocoa) Extract1,2,3, Palmaria palmata (Red Algae) Extract1, Tremella fuciformis sporocarp (Silver Ear Mushroom) Extract1,3, Caffeine, Bisabolol1, Sodium Lactate, Arginine1, Aspartic Acid1, Glycine, Alanine, Serine, Valine1, Proline1, Threonine1, Isoleucine1, Histidine1, Phenylalanine1, PCA1, Sodium PCA1, Cholesterol1, Phosphatidylcholine1,3, Lecithin1,3, Methylglucoside Phosphate, Caprylhydroxamic Acid1, Glyceryl Caprylate1, Alcohol1, Xantham Gum, Citric Acid, Sodium Stearyl Glutamate, Sodium Methyl Stearoyl Taurate, Phenoxyethanol, Hydroxypropylmethylcellulose Stearoxy Ether, Sodium Phytate1, Ethylhexylglycerin1, Tocopheryl Acetate


From one of the most sought-after dermatologists in New York, clean skin-care line MACRENE actives delivers Dr. Macrene Alexiades’s superpowered approach to treating skin—out of the office and into your skin-care cabinet. With products like a do-it-all face cream (to help boost firmness, smooth wrinkles, even skin tone, etc.) packed with 50 active ingredients, a tinted moisturizer that leaves skin absolutely radiant, and a lip-plumping treatment for pillowy, soft lips, every product works overtime for your skin. Many of the active ingredients are sourced from Alexiades’s organic farm in the Hudson Valley, and the brand’s products are housed in recycled-glass jars and printed with biodegradable inks. “You can do it all,” says Alexiades. “I’m never thinking about price point; I’m thinking of excellence.”

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Returns are accepted ​on this product within 30 days from the date that the product was delivered to you. Item must be returned unopened/unused, in its original packaging, along with a completed return form.
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