This is a big, beautiful, Deco-style resort that somehow manages to strike a balance between the glitz of a Waldorf Astoria property and local clout: the structure has been here since the ’20s and is listed in the National Register for Historic Places. The massive, 300+ room compound sits on a private beach, so you can retreat to a lounge chair, or your beautifully appointed guestroom, or the world-class spa whenever the craziness of Duval Street, which is walking distance from the hotel, gets to be too much.

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