Museum of Contemporary Art Chicago
220 E. Chicago Ave., Magnificent Mile
Housed in a Josef Paul Kleihues-designed building in the heart of the city, MCA Chicago is one of the best contemporary art museums in the world. In years past, they've organized everything from the first David Bowie retrospective, to the US debut of Colombian sculptor Doris Salcedo, as well as a major survey of American painter Kerry James Marshall (which they co-organized with the Met and LA's MOCA). We also love MCA for its manageable size—you can easily traverse the major galleries in a couple hours.