66 Mint Plaza, Union Square
There are locations peppered throughout L.A., NYC, and even Tokyo, but Blue Bottle coffee will forever be synonymous with San Francisco, the city that started it all. Perhaps the most groundbreaking of their brews is the chicory-spiked New Orleans cold brew, which comes in a handy single-serving carton. They also make a pretty great granola in-house while the SFMOMA rooftop location is home to Chef Caitlin Freeman’s modern art desserts. Think: a loaf cake made to look like a Mondrian painting and cookies inspired by Richard Serra’s sculptures.
Four Seasons San Francisco
757 Market St., Union Square
This elegant and airy space right in the middle of downtown San Francisco is ideally situated for walking around the heart of the city. There are also the Yerba Buena gardens nearby and a stunning lap pool inside the hotel for when you need a break from sightseeing (there's also a full-on Equinox gym). It's definitely one of the city's best hotels (if not its best).